A recent study in rats concluded that targeted ultrasound may be an effective, non-invasive, drug-free way to increase insulin levels in people with type 2 diabetes.
During pregnancy, parents like to look at the baby for the first time in the mother’s body. This is characterized by special ultrasound waves with frequencies greater than those heard by the human ear. In most people with diabetes, the body does not normally respond to the hormone insulin. In some people, the body does not produce insulin. Insulin is the process by which blood glucose circulates throughout the body.
Glucose is the fuel for the growth and function of these cells. If insulin cannot do its job, blood glucose is formed. Over time, it can damage organs. Vesna Cedric George is a biomedical engineer at the University of Washington. It is based in Washington, DC. Located at. Cedric uses his engineering expertise to solve medical problems. In one of her projects, she focused on the cells that produce and release insulin. These cells, known as beta (ba-ta) cells, live in the pancreas (PAN-kree-us). The organs sitting in the back of the stomach are about 15 centimeters (6 inches) in length.
Other researchers have shown that ultrasound can release signals to brain cells. Cedric and her colleagues wondered if the beta cells would release insulin through an ultrasound. Many diabetes drugs affect beta cells in this way. But these drugs can be expensive to treat, especially for a lifetime. Diabetic drugs often cause unpleasant side effects.
If ultrasound can trigger beta cells to release insulin, it can stop normal diabetes. Zderic argued it would be important. Every person with diabetes can cause serious damage to the heart and kidneys. They may be blind. At that point, most of their beta cells will die. If their body has insulin, they can no longer make it.
Therefore, the cluster group found that the pancreas cells were treated with ultrasound. In new tests, researchers have confirmed that the technology is working – at least in mice. Tania Singh observes, “Common diabetic drug disorders often interfere with the digestive system or damage the kidneys.” Like her mentor, she hopes that ultrasound therapy will someday help prevent the side effects of these drugs.
Need to manage glucose
Every time you eat, your digestive system breaks down food into its chemical building blocks. One of these is glucose. After the intestine is released, glucose passes through the blood to the body parts. For example, the heart rate is 60 beats per minute and requires regular energy supply from food sources.
Glucose must be absorbed into the cells throughout the body and use their chemical energy. Insulin is a glucose sensor. When blood glucose levels rise, insulin acts as a key to unlocking cells and turning them into glucose. It removes the sugar in the blood.
Type 1 diabetes and the body’s immune system kill the insulin-producing beta cells. That means the body doesn’t have the key to controlling glucose. In all types of diabetes, the body produces insulin, but the cells do not respond. The key is broken.
When the glucose withdrawal key is lost or broken, blood sugar levels rise to an abnormal level. High levels can damage tissues.
Previously, Zderic’s team had been developing zip beta cells in a bowl with a continuous ultrasound beam for five minutes. It increased the release of insulin in the cells. Researchers reported the findings two years ago. Singh took the next step: testing whether beta cells do the same thing in healthy mice. The team chose this animal because its pancreas is similar to the human organ.
For the test, they treated one group of mice with ultrasound and the second group did not treat. (Untreated group controls are called controls.) Once the mice were infected, Singh measured the blood insulin level of each animal. She then placed both groups of mice on a small screw and performed an ultrasound examination of their stomachs. She was then treated with ultrasound for five minutes.
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The treatment has increased insulin levels by about 20 percent. This increase coincides with the results for the tested beta cells in a pot. At the same time, insulin levels were decreased in control animals. There was no damage to the pancreas and surrounding organs. At a meeting of the American Acoustics Association in May, Singh described her group’s findings. The meeting took place in Louisville, Ky.